Aqueous Humour Malondialdehyde Level as Oxidative Stress Marker In Types Of Glaucoma

Background: Angle-closure glaucoma is Asia’s most common type of glaucoma, leading to worse damage due to its oxidative stress. Another type is open-angle glaucoma in the second line. The oxidative stress level can be known by malondialdehyde level examination. The study about MDA levels in aqueous humour in primary angle-closure and open angel glaucoma has not been done before. Therefore, the objective of this study was to determine the difference of malondialdehyde levels in aqueous humour between primary open-angle glaucoma and primary angle-closure glaucoma. Methods: This study was an analytical observational study. Nine subjects were primary open-angle glaucoma patients, and ten subjects were primary angle-closure glaucoma patients. The aqueous humour was aspirated from the anterior chamber during trabeculectomy and measured the MDA levels using a spectrophotometer. Data were analyzed by the Mann-Whitney test. Results: There was no significant difference (p=0.095) of MDA levels in aqueous humour between primary open-angle glaucoma (62.913±17.259 μmol/L) and primary angle-closure glaucoma (53.485±9.670 μmol/L). Conclusion: The oxidative stress level in primary open-angle glaucoma and primary angle-closure glaucoma is the same, indicating that the inflammation status in both conditions could be similar.